Emergence during development of the white-adipocyte cell phenotype is independent of the brown-adipocyte cell phenotype

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Emergence during development of the white-adipocyte cell phenotype is independent of the brown-adipocyte cell phenotype.

In mammals, two types of adipose tissue are present, brown and white. They develop sequentially, as brown fat occurs during late gestation whereas white fat grows mainly after birth. However, both tissues have been shown to have great plasticity. Thus an apparent transformation of brown fat into white fat takes place during post-natal development. This observation raises questions about a possi...

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The Genetics of Brown Adipocyte Induction in White Fat Depots

Evidence that adult humans have functional brown adipose tissue has stirred interest in the possibility that the impressive effectiveness of induction of brown adipocytes to reduce obesity in mice may be translated to the human condition. A major focus recently on the identification of signaling and transcription factor that stimulate the induction of brown adipocytes has come from transgenic a...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 2001

ISSN: 0264-6021,1470-8728

DOI: 10.1042/bj3560659